Investigation of hollow mesoporous NiFe2O4 nanospheres fabricated via a template-free solvothermal route as pH-responsive drug delivery system for potential anticancer application

Abstract A novel magnetic-targeted pH-responsive intelligent drug carrier based on hollow mesoporous structured NiFe 2 O 4 nanospheres was designed and developed for potential anticancer treatment in the present study. The were fabricated through a template-free solvothermal approach possible formation mechanism of this structure proposed. products investigated comprehensively their morphology, microstructure, composition magnetic properties using wide series characterization methods. demonstrated to possess well-defined spherical homogeneous particle size distribution, large cavities abundant mesopores, unique superparamagnetic behavior, high saturation magnetization as well good biocompatibility. Due these desirable physicochemical properties, expected be employed vehicle loading delivering doxorubicin hydrochloride (DOX). Drug release behavior evidenced controllable with effective DOX 73.1% 58.8% acidic conditions (pH 4.0 5.5), whereas insufficient 44.7% at neutral atmosphere 7.4) within 48 h. More importantly, DOX-loaded displayed significant anti-proliferation apoptosis effects human breast cancer cells (MCF-7), which further indicated promising application constructed delivery nanocarriers field therapy.